This is all mankind specific advice, take it with a grain of salt but I’ve had a look at the numbers and this is some of the best advice i can give you based on them.
Laboratories do not make your empire great, you do not need to research everything, they are an expensive building, 25,000 population just for it alone, then add the extra 5,000 because it requires a PowerStation.
Once you build them you’re likely not going to demolish them, ever, you’ll upgrade them but their a permanent sunken cost.
For the same pop you can build 10 mines and a power station. This will help your empire far more in the long run then a single lab which generates 1 science an hour. Mines give you a great return on investment.
I generate roughly 50 science an hour, my maths later on is based on this. Preliminary data from my survey shows that this is about the medium, on average synthis players generating more science than other races.
Science is not a focus of mine it has never been and never was, if i have some spare resources i might build a few but by focusing so much on building such an expensive building you are hurting your empire long term, it doesn’t matter if you can have unlocked a shipyard 3 or 4 if you don’t have the resources or infrastructure to build it.
The total cost of all tech trees except weapons and ships is 59,290.3 tech or about 50 days of research time for me. If you make some smart decisions you can easily cut that down to 4,040.4, which ends up at about 81 hours of research time for me. what did I cut out? A large majority of the top upgrades, many have a large research requirements for minimal net gain.
A fair few of the techs you can just not bother with to save time and resources, deep mining, forget about it, planet modification past the first one? not needed.
Simply by not researching tactical coordination and shipyard 4 you save 22,500 research points. 5000 if you don’t research deep mining for F, B, L and Z.
Full farm automation, social theories and megalopolises with their 5 hour upgrade time and high resource cost do not provide a worthwhile return on investment unless you have a planet that is running out of population to spare.
The key thing to take away is; Look at your empire, create a plan and research the tech that will give you the greatest return on investment.